CoQ10 and Fertility: Understanding the Connection | The Yinova Center

“Should I be taking CoQ10 if I’m trying to get pregnant?”

In most cases, the answer is yes.

CoQ10 is a coenzyme found in every cell of the human body that is essential to energy production and cellular function. For people trying to conceive, it can help eggs live up to their potential by supporting the mitochondria, which are the cells’ energy supply. For example, this study found that a higher level of CoQ10 inside developing eggs was associated with higher pregnancy rates.

What is Coenzyme Q10 (CoQ10)?

CoQ10, or ubiquinone as it is also known, is a naturally occurring compound in the body. It is essential for producing adenosine triphosphate (ATP), the primary energy source for cells. CoQ10 is also a powerful antioxidant, protecting cells from oxidative damage. While the body can synthesize CoQ10, its production tends to decrease with age, which has led to interest in its potential role in helping older women conceive.

The Role of CoQ10 in Cellular Health

CoQ10 is primarily found in the mitochondria, often called the cell’s powerhouse, where it helps convert nutrients and oxygen into energy. This energy production is especially critical for cells with high energy demands, such as those in the heart, liver, and ovaries. Ovaries require significant energy for processes like egg maturation and hormone production. By supplementing with CoQ10, we can support optimal mitochondrial function in the ovaries, potentially improving egg quality and overall reproductive health.

The Impact of CoQ10 on Female Fertility

Research on the effect of CoQ10 on female fertility has generated interest among healthcare professionals and those seeking to conceive. Here are some key findings from studies conducted up to 2021:

  • Improved Oocyte (Egg) Quality: Several studies have suggested that CoQ10 supplementation may enhance oocyte quality. Oocytes are the female reproductive cells, and their quality is crucial to female fertility. Improved oocyte quality is associated with better chances of successful fertilization and pregnancy.
  • Aging and Fertility: As women age, their natural CoQ10 levels tend to decline, coinciding with a decline in fertility. Some research indicates that CoQ10 supplementation might help mitigate age-related fertility issues by supporting mitochondrial function in the ovaries.
  • Polycystic Ovary Syndrome (PCOS): CoQ10 has also been investigated as a potential treatment for conditions such as PCOS, which can lead to fertility challenges. While the results are preliminary, CoQ10’s antioxidant and mitochondrial support properties may benefit women with PCOS.
  • Endometrial Health: Adequate CoQ10 levels may also play a role in maintaining the health of the endometrium, the lining of the uterus. A healthy endometrium is essential for successful embryo implantation.

The Impact of CoQ10 on Male Fertility

While much of the focus has been on female fertility, CoQ10 may also positively impact male fertility. Sperm cells, like eggs, rely on energy production and protection from oxidative stress. Here’s how CoQ10 may affect male fertility:

  • Sperm Motility: Some studies have suggested that CoQ10 supplementation could improve sperm motility, which is crucial for sperm to fertilize the egg. Improved sperm motility may increase the chances of conception.
  • Sperm Count and Quality: CoQ10’s antioxidant properties may help protect sperm from oxidative damage, potentially improving sperm count and quality.

CoQ10 Softgels

Choosing the Right CoQ10 Supplement

If you’re considering CoQ10 supplementation to support fertility, choosing the right product is essential. Here are some tips:

  • Ubiquinol vs. Ubiquinone: CoQ10 supplements come as ubiquinol and ubiquinone. Ubiquinol is the active form, which the body may more readily absorb. However, both forms have shown potential benefits for fertility.
  • Dosage: The appropriate dosage can vary from person to person. It’s advisable to consult with a healthcare provider who can recommend the correct dosage based on your specific needs. Fertility specialists recommend taking between 100mg and 600mg of CoQ10 daily. At Yinova, we recommend 400mg daily or four of our soft gel tablets.
  • Quality Matters: Choose a reputable brand that undergoes third-party testing to ensure product quality and purity. At Yinova, our CoQ10 is combined with Vitamin E and is specially formulated to promote easier absorption and stability.
  • Consistency: It takes 90 days for sperm and eggs to develop so people see the best results after taking CoQ10 consistently for over three months.

Conclusion

Coenzyme Q10, or CoQ10, has garnered attention for its potential role in improving fertility, both in women and men. While research on this topic is ongoing, existing studies suggest that CoQ10 may support mitochondrial function, enhance oocyte and sperm quality, and mitigate age-related fertility decline. However, it’s crucial to approach CoQ10 supplementation as part of a broader strategy for optimizing fertility, including a healthy lifestyle, balanced diet, and regular exercise.


References

  1. Rodríguez-Varela C, Labarta E. Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality? International Journal of Molecular Sciences. 2021; 22(17):9541. https://doi.org/10.3390/ijms22179541
  2. Alexandria M. Brown & Helen E. McCarthy (2023) The Effect of CoQ10 supplementation on ART treatment and oocyte quality in older women, Human Fertility
  3. Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RF, Jurisicova A. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015 Oct;14(5):887-95. doi: 10.1111/acel.12368. Epub 2015 Jun 26. PMID: 26111777; PMCID: PMC4568976.
  4. Izadi A, Ebrahimi S, Shirazi S, Taghizadeh S, Parizad M, Farzadi L, Gargari BP. Hormonal and Metabolic Effects of Coenzyme Q10 and/or Vitamin E in Patients With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2019 Feb 1;104(2):319-327. doi: 10.1210/jc.2018-01221. PMID: 30202998.
  5. Elham Rahmani, Mehri Jamilian, Mansooreh Samimi, Maryam Zarezade Mehrizi, Esmat Aghadavod, Elmira Akbari, Omid Reza Tamtaji & Zatollah Asemi (2018) The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome, Gynecological Endocrinology, 34:3, 217-222
  6. Ahmadi S, Bashiri R, Ghadiri-Anari A, Nadjarzadeh A. Antioxidant supplements and semen parameters: An evidence-based review. Int J Reprod Biomed. 2016 Dec;14(12):729-736. PMID: 28066832; PMCID: PMC5203687.
  7. Safarinejad, M.R. The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study.https://link.springer.com/article/10.1007/s11255-011-0081-0 Int Urol Nephrol 44, 689–700 (2012)
  8. Aby Lewin, Haim Lavon, The effect of coenzyme Q10 on sperm motility and function, Molecular Aspects of Medicine, Volume 18, Supplement 1, 1997, Pages 213-219,

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